CD4 responses against IDO
نویسنده
چکیده
Natural indoleamine-2,3-dioxygenase (IDO)-reactive CD4(+) T cells have been shown to release interferonγ (IFNγ), tumor necrosis factor α (TNFα), as well as interleukin 17 (IL-17). In some individuals, these cells also demonstrated the ability to suppress IL-10 production. IDO-specific CD4(+) helper T cells among peripheral blood lymphocytes may participate in immunoregulatory networks by delaying the immune suppressive actions of IDO. However, IDO-specific CD4(+) T cells may also have a regulatory phenotype, de facto exerting immunosuppressive functions.
منابع مشابه
Natural CD4+ T-Cell Responses against Indoleamine 2,3-Dioxygenase
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2012